1075-35-0, 5-Chloro-2-methylindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: General procedure for C3-dialkylation of indoles. In a flame dried flask, the imidate (2.5 equiv)was dissolved in anhydrous DCE (0.3 M) followed by the addition of the indole (1.0 equiv). To thissolution freshly distilled TMSOTf (1.0 equiv) was added and the resulting mixture was stirred atroom temp. or heated to reflux for 3 h. After cooling to room temperature, the reaction mixture wasquenched with 10 mL 1MNaOH. The organic layer was separated and the aqueous layer was extractedwith DCM (3 5 mL). The combined organic layers were dried over sodium sulfate, filtered andconcentrated. The residue was purified by silica gel chromatography using the listed solvent system., 1075-35-0
The synthetic route of 1075-35-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Suzuki, Tamie; Mate, Nilamber A.; Adhikari, Arijit A.; Chisholm, John D.; Molecules; vol. 24; 22; (2019);,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles