118414-82-7, MK-886 is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a mixture of 3-[3-rert-butylsulfanyl-1-(4-chloro-benzyl)-5-isopropyl- lH-indol-2-yl]-2,2-dimethyl- propionic acid (1.26 mmol) and 6-bromohexyl nitrate (F. Conrad Engelhardt et a, J. Org. Chem., 2006, 71, 480-491; 1.4 mmol) in DMF (5 ml) was added CsCO3 (6 mmol). The mixture was stirred at room temperature over night. H2O was added and the reaction mixture was extracted with ethyl acetate. The extracts were washed with brine, dried over Na2SO4, filtered, and the solvent was evaporated under reduced pressure. The residue obtained was purified by silica gel chromatography (25% EtOAc in hexanes) to give the desired product.[0400] 1H NMR delta 7.63 (s, IH), 7.19 (d, 2H), 7.02 (s, 2H), 6.74 (d, 2H), 5.32 (s, 2H), 4.38 (t, 2H), 3.97 (t, 2H),3.25 (s, 2H), 3.01 (m, IH), 1.62-1.15 (m, 29H)., 118414-82-7
The synthetic route of 118414-82-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; AMIRA PHARMACEUTICALS, INC.; WO2008/67566; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles