With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1265231-91-1,3-(Dimethylamino)-2-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)acrylonitrile,as a common compound, the synthetic route is as follows.
2-(1-Fluorocyclopropyl)-5-hydrazinyl-1H-benzo[d]imidazole dihydrochloride 10d (706mg, 2.5 3mmol) and (E)-3-(dimethylamino)-2-(1-(phenylsulfonyl)-1H-indole-2-carbonyl)acrylonitrile 1f (959mg, 2.53mmol, prepared according to the published patent application ) were suspended in 13mL of absolute ethanol, the reaction solution was refluxed for 4 hours. The reaction solution was cooled down to room temperature, solid precipitated. The solution was subjected to suction filtration, the filter cake was washed with ethanol (15mL*3) then was subjected to infrared drying to obtain (5-amino-1-(2-(1-fluoropropyl)-1H-benzo[d]imidazol-5-yl)-1H-pyrazol-4-yl)(1-(phenylsulfonyl)-1H-indol-2-yl)methanone 10e (493mg, black solid), yield: 36%. MS m / z (ESI): 540.8 [M + 1]
1265231-91-1, The synthetic route of 1265231-91-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Zhejiang Hisun Pharmaceutical Co., Ltd; CHEN, Lei; GUAN, Dongliang; BAI, Hua; YAN, Xing; MIAO, Shuai; ZHU, Songsong; (54 pag.)EP3339305; (2018); A1;,
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