14618-45-2, 3-(Trifluoroacetyl)indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 2,2,2-trifluoro-1-(1H-indol-3-yl)ethanone (0.20 g, 0.938 mmol) in THF (1 mL) inan ice-bath was added sodium borohydride (71.00 mg, 1.877 mmol) under N2. Then boron trifluoridediethyl ether (0.357 mL, 2.815 mmol) was added dropwise. The reaction was let stirred for 2 h whilewarmed to room temperature. The mixture was poured into a mixture of ice-water and 5% aqueousNaHCO3 and extracted with ethyl acetate. The combined organics were concentrated. The residue waspurified by silica gel column chromatography to give the title compound (90 mg). LCMS m/z = 200.4[M+H]+; 1H NMR (400 MHz, CD3OD) delta ppm 3.57 (q, 2H, J = 11.1 Hz), 7.04 (t, 1H, J = 7.4 Hz), 7.12 (t, 1H, J= 7.3 Hz), 7.20 (s, 1H), 7.37 (d, 1H, J = 8.0 Hz), 7.54 (d, 1H, J = 7.9 Hz).
14618-45-2, As the paragraph descriping shows that 14618-45-2 is playing an increasingly important role.
Reference：
Article; Dang, Huong; Feichtinger, Konrad; Frazer, John; Grottick, Andrew J.; Kasem, Michelle; Le, Minh; Lehman, Juerg; Morgan, Michael E.; Ren, Albert; Sage, Carleton R.; Schrader, Thomas O.; Semple, Graeme; Unett, David J.; Whelan, Kevin T.; Wong, Amy; Zhu, Xiuwen; Bioorganic and medicinal chemistry letters; (2020);,
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