With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1477-49-2,3-Indoleglyoxylic Acid,as a common compound, the synthetic route is as follows.
General procedure: 1 equiv of arylglyoxylic acid 12a was dissolved in 2 ml NMP and 1.1 equiv of CDI were added. The mixture was stirredat rt for 1 h followed by addition of 1 equiv of a-ketoamine12b. After stirring at rt over night water was added slowly to precipitate diketoamide 12c which was filtered off and washed with methanol and diethylether. Alternatively, the diketoamide was extracted by ethylacetate and purified by Flash chromatography.
1477-49-2, 1477-49-2 3-Indoleglyoxylic Acid 73863, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Article; Johannes, Eugen; Horbert, Rebecca; Schlosser, Joachim; Schmidt, Dorian; Peifer, Christian; Tetrahedron Letters; vol. 54; 31; (2013); p. 4067 – 4072;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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