15861-24-2, Indole-5-carbonitrile is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,15861-24-2
Compound 1 (142.2g, 1.0mol) was dissolved in dichloromethane (1.5L), the internal temperature was controlled at 0-5 C, and anhydrous zinc chloride (150g, 1.1mol) was added.After the addition was completed, the temperature was lowered to about -10 C, and 1-bromo-4-chlorobutane (Compound 3) (188.6g, 1.1mol) was added dropwise.After the dropwise addition was completed, the temperature was raised to a reaction temperature of 0 C and the reaction was conducted for 2 hours.After the reaction was completed, dichloromethane (0.5 L) was diluted, and ice water (1 L) was destroyed. Subsequently, 1 N sodium hydroxide solution was added to neutralize to adjust pH = 7, and extraction and liquid separation were performed.The organic phase was washed with saturated brine (0.5 L) and separated.After the organic phase was concentrated to dryness, the residue was recrystallized from isopropyl acetate (0.5 L),205 g of the product (I) was obtained, the yield was 88%, and the HPLC purity was 99.62%.
As the paragraph descriping shows that 15861-24-2 is playing an increasingly important role.
Reference£º
Patent; Shanghai Institute of Technology; Fang Yahui; Li Huixia; (6 pag.)CN111087340; (2020); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles