With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16096-32-5,4-Methyl-1H-indole,as a common compound, the synthetic route is as follows.
General procedure: A mixture of xanthen-9-ol 1 (0.040 g, 0.2 mmol) and 2a (0.024 g, 0.2 mmol) was stirred in a tube at room temperature in BmimBF4 (0.5 mL) until the disappearance of the starting 2a (24 h, checked by thin-layer chromatography, TLC). After completing, the reaction mixture was extracted by ethyl ether (3¡Á15 mL), then concentrated and isolated by flash chromatograph to afford the pure product 3a (0.054 g, yield: 92%).
16096-32-5, 16096-32-5 4-Methyl-1H-indole 85282, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Article; Liu, Ling-Yan; Wang, Bing; Yang, Hong-Mei; Chang, Wei-Xing; Li, Jing; Tetrahedron Letters; vol. 52; 43; (2011); p. 5636 – 5639;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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