With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16136-52-0,4-Cyanoindole,as a common compound, the synthetic route is as follows.
EXAMPLE 88 1-Benzyl-4-cyanoindole Following a procedure and using relative proportions of starting materials similar to those described in Example 65, but using 4-cyanoindole as starting material, the title compound was obtained in a yield of 94%. Nuclear Magnetic Resonance Spectrum (CDCl3, 270 MHz), delta ppm: 5.37 (2H, singlet), 6.77 (1H, doublet, J=3.4 Hz), 7.05-7.50 (9H, multiplet).
16136-52-0, 16136-52-0 4-Cyanoindole 3817602, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; Sankyo Company, Limited; US5877199; (1999); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles