16732-69-7, Ethyl 7-bromo-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
i) Preparation of ethyl 7-cyclopropyl- 1 H-indole-2-carboxylate (1220) [00217] A mixture of ethyl 7-bromo-1 H-indole-2-carboxylate (300 mg, 1 .12 mmol), cyclopropylboronic acid (192.23 mg, 2.24 mmol), 2M Na2C03 (2.8 ml) and Pd(dppf)CI2 (40.94 mg, 0.06 mmol) in dioxane (9.7 mL) was purged with argon then subjected to microwave irradiation at 100 C for 2 h. The resulting mixture was filtered over celite, rinsing with EtOAc and water. The filtrate was partitioned between EtOAc and 1 M HCI. The aqueous phase was extracted with EtOAc and the combined organic extracts washed with brine, dried over Na2S04, filtered and concentrated under reduced pressure. The residue was taken up in DCM, adsorbed onto silica and purified by flash chromatography (Telos 12 g, EtOAc in heptane, 0- 15%) to give the title compound contaminated with an unknown related impurity. The material was used in the next step without further purification. ii) Preparation of ethyl 7-cyclopropyl-3-iodo- 1 H-indole-2-carboxylate
16732-69-7, The synthetic route of 16732-69-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; OXFORD UNIVERSITY INNOVATION LIMITED; BREM, Juergen; RYDZIK, Anna M.; MCDONOUGH, Michael A.; SCHOFIELD, Christopher J.; MORRISON, Angus; HEWITT, Joanne; PANNIFER, Andrew; JONES, Philip; (171 pag.)WO2017/93727; (2017); A1;,
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