16732-70-0, Ethyl 5-bromo-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 5-bromoindole-2-carboxylic acid ethyl ester (3.48 g, 13 mmol), 4-terr-butylphenylboronic acid (4.63 g, 26 mmol), K3PO4 (9.93 g, 45 mmol), Pd(OAc)2 (146 mg, 0.65 mmol), tri-o-tolylphosphine (396 mg, 25 30 1.3 mmol), EtOH (20 ml) and toluene (10 mL) was stirred under argon for 20 min at rt foolowed by heating at 100 0C for 24 h. The mixture was allowed to cool to rt, poured into NaHCO3 (aq, sat) and extracted with EtOAc. The combined extracts were washed with water and brine, dried (Na2SO4), concentrated and purified by chromatography to give the sub-title compound (3.27 g, 78%)., 16732-70-0
The synthetic route of 16732-70-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BIOLIPOX AB; WO2006/77367; (2006); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles