With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1953-54-4,5-Hydroxyindole,as a common compound, the synthetic route is as follows.
General procedure: K2CO3 (1.56 g, 11.3 mmol) was added to indoline (3.8 mmol) and benzyl bromide (5.6 mmol) in acetone (50 mL). The solution was heated under reflux overnight. After the reaction, undissolved solid was filtered off, and the filtrate was evaporated under reduced pressure. The crude product was purified by column chromatography on silica gel using hexane/ethyl acetate (10:1, v/v) as eluent. Yield=68%. 1H NMR (CDCl3, 400 MHz): delta=8.04 (1H, br), 7.53 (2H, d, J=7.4 Hz), 7.22-7.47 (5H, m), 7.16 (1H, t, J=2.7 Hz), 7.00 (1H, dd, J=2.2 and 8.8 Hz), 6.51 (1H, m), 5.15 (2H, s). 13C{1H} NMR (CDCl3, 100 MHz) delta=153.4, 137.8, 131.2, 128.6, 128.3, 127.9, 127.7, 125.0, 113.1, 111.8, 104.0, 102.4, 71.0, 1953-54-4
1953-54-4 5-Hydroxyindole 16054, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; THE REGENTS OF HE UNIVERSITY OF CALIFORNIA; Nomura, Daniel K.; Zoncu, Roberto; Rpberts, Allison M.; Cho, Kelvin F.; Chung, Yik Sham Clive; Shin, Hijai; Croze, Benjamin; (127 pag.)US2019/112268; (2019); A1;,
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