23077-44-3, 6-Fluoro-1H-indole-3-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
DMF (0.1 mL) was added to a stirring mixture of 6-fluoroiindole-3- carboxylic acid (3.500 g, 19.5 mmol, l .Oequiv.) and oxalyl chloride (3.306 ml, 39.1 mmol, 2.0 equiv.) in dichloromethane (40 mL) under nitrogen at 0oC(ice bath tmeperature). After 2 hours the reaction was concentrated to dryness. The residue was taken up in DCM (20 mL) and cooled to 0C and tropine (8.276 g, 58.6 mmol, 3.0 equiv.) was added as a solution in DCM (25mL) with stirring. The reaction mixture was allowed to come to room temperature and stirred overnight. The reaction mixture was washed with saturated sodium bicarbonate and the solvents removed under reduced pressure. The residue was titurated with ethyl acetate and hexanes to get the product as a tan colored solid (2.34g, 39.6%). 1H MR (DMSO-d6, 300 MHz): 11.94 (s, 1H), 8.01-7.96 (m, 2H), 7.27 (dd,J=9.9 & 2.4 Hz, 1H), 7.08-7.01 (m, 1H),5.06 (t, J=5.4 Hz, 1H), 3.09 (s, 2H), 2.21 -1.99 (m, 9H), 1.75-1.70 (m, 2H). LC/MS: 303.6 (M+l).
23077-44-3, 23077-44-3 6-Fluoro-1H-indole-3-carboxylic acid 28806318, aindole-building-block compound, is more and more widely used in various.
Reference£º
Patent; BUCK INSTITUTE FOR RESEARCH ON AGING; JOHN, Varghese; BREDESEN, Dale, E.; SPILMAN, Patricia, R.; JAGODZINSKA, Barbara; (85 pag.)WO2017/197177; (2017); A1;,
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