245-08-9, 5H-Pyrido[3,2-b]indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a two-necked 250 ml flask7 g (42 mmol) of delta-carboline,1-bromo-3-nitrobenzene (1-bromo-3-nitrobenzene)9.3 g (46 mmol) of CuI, 0.52 g (3 mmol) ,0.94 g (5 mmol) of 1,10-phenanthroline,22 g (104 mmol) of K3PO4 and 120 ml of dioxane were added, and the mixture was refluxed at 80 to 100 DEG C for 24 hours in a nitrogen atmosphere.After the reaction was completed, the reaction product was dissolved in methylene chloride (MC) and filtered using Celite. The filtered solution was distilled under reduced pressure and extracted with MC and distilled water.The extracted MC layer was dehydrated with MgSO4, and then purified by vacuum distillationThe solvent was removed to give a yellow solid. The solid was separated from the white solid (1) (7.5 g, yield: 65%) by column chromatography., 245-08-9
As the paragraph descriping shows that 245-08-9 is playing an increasingly important role.
Reference£º
Patent; Raepto Co., Ltd.; Oh Yu-jin; Han Gap-jong; (27 pag.)KR2019/28878; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles