26807-73-8, 1-Benzyl-1H-indol-5-amine is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1-benzyl-1H-indole-5-amine (250 mg, 1.12 mmol, 1.0 equiv.), k2CO3 (186 mg, 1.34 mmol,1.2equiv.) Dissolved in anhydrous CH3CN, the new 2,5-dichlorobenzoyl chloride (271mg, 1.29mmol, 1.15equiv.) was soluble.The anhydrous DCM was slowly added dropwise at 0 C and stirred under nitrogen for 2 hours. The TLC monitors the reaction in real time. After the reaction, diluted with water, the right amountEthyl acetate extraction three times, the organic phase is combined, washed with water, saturated NaHCO3 solution, saturated NaCl solution, organic layerDrying with anhydrous NaSO4, distilling under reduced pressure to give a crude product, which was purified by silica gel column to afford N-(1-benzyl-1H-indol-5-yl)-2,5-dichlorobenzamide (400 mg, yield: 89 %).
26807-73-8, The synthetic route of 26807-73-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Fudan University; Wang Yonghui; Yu Fazhi; Li Wei; (38 pag.)CN109232358; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles