Analyzing the synthesis route of 2795-41-7

2795-41-7, As the paragraph descriping shows that 2795-41-7 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2795-41-7,6-Fluoroindole-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: The van Leusen reaction was conducted as describedpreviously [37]. Aromatic aldehyde (3 mmol) was mixed withamine (15 mmol) in 20 mL of dry methanol. The reaction mixturewas left overnight to complete imine formation, although thisprocess can be monitored by this layer chromatography (TLC) (SiO2/CHCl3). Anhydrous K2CO3 (3 mmol) and TosMIC (tosylmethylisocyanide,3 mmol) were subsequently added. The mixture was stirredfor an additional 8 h, diluted with 50 mL of H2O, and extractedthree times with 20 mL of ethyl acetate. The combined extractswere washed twice with 20 mL of H2O, and once with 20 mL ofbrine, treated with anhydrous magnesium sulfate and evaporated.The final products were purified either by trituration under a 2:1hexane:isopropanol mixture, or chromatography on a short silicagelbed. The unreacted aldehydes were eluted with ethyl acetate orchloroform, and a mixture of AcOEt:MeOH or CHCl3:MeOH wasthen applied to elute the product.

2795-41-7, As the paragraph descriping shows that 2795-41-7 is playing an increasingly important role.

Reference:
Article; Hogendorf, Adam S.; Hogendorf, Agata; Popio?ek-Barczyk, Katarzyna; Ciechanowska, Agata; Mika, Joanna; Sata?a, Grzegorz; Walczak, Maria; Latacz, Gniewomir; Handzlik, Jadwiga; Kie?-Kononowicz, Katarzyna; Ponimaskin, Evgeni; Schade, Sophie; Zeug, Andre; Bijata, Monika; Kubicki, Maciej; Kurczab, Rafa?; Lenda, Tomasz; Staro?, Jakub; Bugno, Ryszard; Duszy?ska, Beata; Pilarski, Bogus?aw; Bojarski, Andrzej J.; European Journal of Medicinal Chemistry; vol. 170; (2019); p. 261 – 275;,
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