310886-79-4, Methyl 5-fluoro-1H-indole-3-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
0.384 g (12 [MMOL)] of sodium hydride, at 75% by mass in liquid petroleum jelly, is added at a temperature in the region of [20C] under an argon atmosphere to a solution of 2.26 g [(11.] 7 [MMOL)] of [5-FLUORO-3-METHOXYCARBONYL-1] [H-INDOLE] in 60 cm3 of dimethylformamide. After stirring at a temperature in the region [OF 40C] for 0.5 hour, 1.98 g (12 [MMOL)] of 4-chloroquinoline are added. After stirring at a temperature in the region of [120C] for 6 hours, the reaction mixture is poured into 200 cm3 of water and extracted with 200 cm3 of ethyl acetate. The organic phase is washed with 3 times 100 cm3 of water and is then dried over anhydrous magnesium sulphate, filtered and concentrated to dryness under reduced pressure (2.7 kPa) to give 3. 5 g of a brown solid which is purified by silica gel chromatography (eluent : dichloromethane). After concentrating the fractions under reduced pressure, 1. 6 g of [5-FLUORO-3-] [METHOXYCARBONYL-1-(QUINOL-4-YL)-1 H-INDOLE] are obtained in the form of a beige-coloured solid [MELTING AT 172C.], 310886-79-4
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Reference£º
Patent; AVENTIS PHARMA DEUTSCHLAND GMBH; WO2004/7480; (2004); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles