387-43-9, 4-Fluoroindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: To the 10 ml Schlenk tube containing the substrate indole 1a (0.25 mmol, 30 mg), 4-chloroaniline 2a (0.75 mmol, 96 mg) and acetonitrile (4 ml) was added 1-fluo-1,2-benziodoxol-3-(1H)-one (0.89 mmol, 237 mg), the mixture was stirred at room temperature as monitored by TLC. The solution was then quench by NaHCO3 solution and extracted with EtOAc, the combined organic layers were dried over Na2SO4, filtered, and evaporated under vaccum, the residue was purified by column chromatography (eluents: n-hexane/ethyl acetate = 50/1 v/v) on silica gel to afford the desired product 3a.
The synthetic route of 387-43-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Jiang, Xinpeng; Li, Guizhou; Yu, Chuanming; Tetrahedron Letters; vol. 59; 15; (2018); p. 1506 – 1510;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles