With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.387-43-9,4-Fluoroindole,as a common compound, the synthetic route is as follows.
Take 135 mg (1 mmol) of 4-fluoroindole, 132.6 mg (1.3 mmol) of 5-hydroxy-2-pentanone and 20.48 mg (0.04 mmol) of tris(pentafluorophenyl)boron in a 10 mL reaction tube. The reaction was stirred at 40 C, and monitored by TLC until hydrazine disappeared, extracted with 3¡Á20 mL ethyl acetate, and the organic phase was washed with saturated brine.The organic layer was dried over anhydrous sodium sulfate, and the solvent ethyl acetate was evaporated to dryness (methanol ethyl ether: 20:1) to afford 3-(tetrahydro-2-methyl-2-furanyl)-4-fluoro-1H-indole product 175 mg, yield: 80%.
387-43-9, As the paragraph descriping shows that 387-43-9 is playing an increasingly important role.
Reference£º
Patent; Huazhong University of Science and Technology; Wang Shijun; Xia Sang; Tang Xiangying; (18 pag.)CN109912579; (2019); A;,
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