With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.393553-57-6,6-Bromo-4-methoxy-1H-indole,as a common compound, the synthetic route is as follows.
NaH (96mg, 4mmol) was suspended in 7mL DMF in a round bottom flask and cooled to 0C. 6-bromo-4-methoxy-1H-indole (0.75g, 3.3mmol) was added dropwise as a solution in DMF (ImL). Ethyl iodide (0.28mL, 3.5mmol) was added dropwise and the reaction mixture was stirred for 10 min. Volatiles were removed under reduced pressure and the residue partitioned between DCM and water. The aqueous layer was extracted with DCM and the combined organics layers were dried over MgSO4, filtered, and evaporated to give a red oil. The resulting residue was purified on silica gel column chromatography eluting with hexanes/ethyl acetate (0-10%) to afford pure 36-2 (584mg, 70%) as a white solid., 393553-57-6
As the paragraph descriping shows that 393553-57-6 is playing an increasingly important role.
Reference：
Patent; GALENEA CORPORATION; ELDER, Amy; HARRIMAN, Geraldine; LEIT, Silvana; LI, Jie; SARD, Howard; ZHANG, Yiliang; WILSON, Doug; WO2011/19738; (2011); A1;,
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