399-76-8, 5-Fluoroindole-2-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5-Fluorondole-2-carboxylic acid (5.00g, 27.91mmol) was added to ethanol (50mL) at 0 ¡ãC. SOCl2 (9.84g, 82.71mmol) was added to the mixture and the reaction mixture was warmed to reflux and stirred for 5 hours. TLC showed the reaction was complete, the reaction mixture was concentrated, and saturated aqueous NaHCO3 solution (15mL) was added thereto. The resulting mixture was extracted with DCM (100mL * 2) and the organic phase was dried over anhydrous sodium sulfate and concentrated to deliver the title compound (light yellow solid, 5.50g, yield 85.60percent). 1H-NMR (400 MHz, CDCl3) delta 9.00 (br. s., 1 H), 7.31 – 7.39 (m, 2 H), 7.19 (d, J=1.2Hz, 1 H), 7.10 (td, J=9.0, 2.4 Hz, 1 H), 4.43 (q, J=7.1 Hz, 2 H), 1.43 (t, J=7.1 Hz, 3 H)., 399-76-8
399-76-8 5-Fluoroindole-2-carboxylic acid 1820, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD; DING, Charles Z.; CHEN, Shuhui; ZHAO, Baoping; LIU, Xile; XIAO, Linxia; DING, Chao; WANG, Fei; LI, Jian; (153 pag.)EP3290419; (2018); A1;,
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