With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.40913-43-7,1-Ethyl-1H-indole-2-carbaldehyde,as a common compound, the synthetic route is as follows.
Intermediate 2 l-Ethyl-3-fluoro-l//-indole-2-carbaldehydeA 50 mL round bottom flask was charged with 1 -ethyl- 1 H- indole-2-carbaldehyde (Intermediate 1, 524 mg, 3.03 mmol) and Selectfluor (1.29 g, 3.64 mmol). MeCN (6.0 mL) was added, and the mixture was allowed to stir at room temperature. After 90 min, the solvent was removed in vacuo, and the residue was partitioned between EtOAc and H2O, and the aqueous layer was further extracted with EtOAc. The combined organic layers were washed with brine, dried (MgSO4), filtered, and concentrated. The crude material was purified by silica gel chromatography (gradient elution; Rf in 95:5 hexanes:EtOAc = 0.42) to give a colorless solid (191 mg, 33%) of 90% purity (remainder is unreacted starting material). 1H NMR (400 MHz, CDCl3) delta 1.31 – 1.39 (m, 3 H) 4.52 (q, J=7.07 Hz, 2 H) 7.16 (m, 1 H) 7.34 (m, 1 H) 7.38 – 7.45 (m, 1 H) 7.70 (m, 1 H) 10.08 (s, 1 H). M/Z 191.
40913-43-7, As the paragraph descriping shows that 40913-43-7 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/59238; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles