434958-85-7, N-Boc-5-Hydroxyindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a 250 mL flask was placed terf-butyl 5-(benzyloxy)-1H-indole-1-carboxylate (3.3g, 14 mmol) in 100 mL of acetone. 1,3-Dibromopropane (5.74 mL, 56.6 mmol) wasadded, followed by cesium carbonate (5.5 g, 17 mmol). The reaction was heated toreflux for 5 h. The reaction was cooled to room temperature and diluted with water (200mL). The mixture was transferred to a separatory funnel and extracted with ethyl acetate(2 x 150 mL). The combined organics were dried (MgSO4), filtered, and evaporated.The residue was then purified via flash chromatography to provide 4.7 g of terf-butyl 5-(3-bromopropoxy)-1H-indole-1-carboxylate (94%). 1H-NMR (DMSO-d6) 5 7.99-7.89 (d, 1H),7.61 (s, 1H), 7.17 (s, 1H), 6.98-6.91, (d, 1H), 6.62 (s, 1H), 4.16-4.05 (t, 2H), 3.64 (t, 2H),2.37-2.20 (m, 2H). LCMS RT= 3.55 min; [M]+= 254.1.
434958-85-7, As the paragraph descriping shows that 434958-85-7 is playing an increasingly important role.
Reference：
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2005/51957; (2005); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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