With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52415-29-9,6-Bromoindole,as a common compound, the synthetic route is as follows.
52415-29-9, To a stirred suspension of 60% sodium hydride (4.88 g, 122 mmol) in tetrahydrofuran (1 50 mL) was added 6-bromoindole (1 5.0 g, 76.5 mmol) portionwise, followed by methyl iodide (1 1.9 g, 83.8 mmol) dropwise and the mixture stirred at room temperature for 16 h. After this time, the reaction was poured into ice-cold water and extracted with ethyl acetate (2 x 100 mL). The combined organic layers were washed sequentially with water, then brine and dried over sodium sulfate. The drying agent was removed by filtration and the filtrate concentrated under reduced pressure to afford 6-bromo-l -methyl -1 H-indole as a pale red solid: NMR (400 MHz, CDC13) d 7.49 (m, 2H), 7.22 (dd, J = 8.0, 1.6 Hz, 1 H), 7.04 (d, J = 3.2 Hz, 1 H), 6.47 (d, J = 3.2 Hz, 1 H), 3.77 (s, 3H).
The synthetic route of 52415-29-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GILEAD SCIENCES, INC.; BLOMGREN, Peter; CURRIE, Kevin, S; KROPF, Jeffrey, E.; LEE, Seung, H.; MITCHELL, Scott, A.; SCHMITT, Aaron, C.; XU, Jianjun; ZHAO, Zhongdong; WO2011/112995; (2011); A1;,
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