With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6127-19-1,6-Bromo-2-methyl-1H-indole,as a common compound, the synthetic route is as follows.
6127-19-1, To a 100 mL round-bottom flask purged with N2 was placed a solution of 6-bromo-2- methyl-1H-indole (1.00 g, 4.76 mmol) and DMAP (58 mg, 0.47 mmol) in THF (15 mL), followed by the addition of Boc2O (1.565 g, 7.17 mmol). The resulting solution was stirred at rt for 2 h then the solvent was removed under reduced pressure. The crude product was purified by column chromatography affording 1.32 g (89%) of the title compound as a yellow solid. Mass Spectrum (LCMS, ESI pos.): Calcd. for C14H17BrNO2: 310; found: 310 [M+H].
6127-19-1 6-Bromo-2-methyl-1H-indole 271554, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; PROTEOSTASIS THERAPEUTICS, INC.; CULLEN, Matthew; BASTOS, Cecilia M.; PARKS, Daniel; MUNOZ, Benito; (0 pag.)WO2020/6296; (2020); A1;,
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