With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7135-31-1,2-Chloro-1H-indole,as a common compound, the synthetic route is as follows.
7135-31-1, General procedure: Intermediate 1-1 (5.0 g, 0.018 mol), 4-bromo-N,N-dip-tolylaniline (12.5 g, 0.036 mol), Pd(dba)2 (0.8 g, 0.0009 mol), sodium-tert-butoxide (3.5 g, 0.052 mol) in TOL 200 ml was reacted with stirring for 4 hours at 95 C. Reaction after H20:MC column purification after separation of to the compounds (n-HEXANE: MC) 11.2 g (75% yield) of compound 1 are obtained. 2-chloro-1H-indole (3.0 g, 0.020 mol) bromobenzene (3.1 g, 0.020 mol) for inserting and removing manufacturing e.g. in the embodiment 1-(2) the same method used in the synthesis of
The synthetic route of 7135-31-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; P&H tech; Hyeon, Seo Young; Jong, Song Ok; Oh, Hyeon Jin; (92 pag.)KR2015/131700; (2015); A;,
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