938465-52-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.938465-52-2,1-Chloro-5H-pyrido[4,3-b]indole-4-carboxamide,as a common compound, the synthetic route is as follows.
To a solution of 1,4,8-triazaspiro[5.Sjundecan-5-one (30 mg, 0.l8mmol) inNMPmL) was added 1-chloro-5H-pyrido[4,3-bjindole-4-carboxamide (44 mg, 0.l8mmol) andDIEA (70 mg, 0.S4mmol), and the mixture was heated under microwave irradiation for 1.5 h at150 C. The reaction solution was purified by prep-HPLC to afford 1-(5-oxo-1,4,8-triazaspiro[5 . Sjundecan-8-yl)-5H-pyrido[4,3-bjindole-4-carboxamide. MS: 379.3 [M+Hjt 1HNMR (400 MHz, DMSO-d6) 3 11.93 (s, 1H), 9.67 (br. s., 1H), 8.70 (s, 1H), 8.54 (br. s., 1H),8.19 (br. s., 1H), 8.05 (d, J=7.8 Hz, 1H), 7.83 (d, J=8.0 Hz, 1H), 7.54 (br. s., 1H), 7.48 (t, J7.4Hz, 1H), 7.38 – 7.31 (m, 1H), 4.39 (d, J=14.1 Hz, 1H), 3.93 (d, J=12.5 Hz, 2H), 3.56 – 3.49 (m,2H), 3.45 (br. s., 2H), 2.98 (t, J=11.5 Hz, 1H), 2.40 -2.21 (m, 2H), 2.20 – 2.05 (m, 1H), 1.84 (d,J13.1 Hz, 1H) ppm.
938465-52-2 1-Chloro-5H-pyrido[4,3-b]indole-4-carboxamide 59198457, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; KOZLOWSKI, Joseph; KIM, Ronald; GAO, Xiaolei; BOGA, Sobhana Babu; YU, Younong; WU, Hao; LIU, Shilan; YANG, Chundao; (102 pag.)WO2016/164284; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles