With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.93957-49-4,3-(4-Fluorophenyl)-1-isopropyl-1H-indole,as a common compound, the synthetic route is as follows.,93957-49-4
Temperature 25 ¡À 5 C, to a 2000L reactor in 1,2 Dichloroethane 504.0kg (5mL / g), the main material of 3- (4-fluorophenyl) -1-isopropyl–1H- indole 80kg (315.8mol, 1.0equiv. ) And N- bromosuccinimide 67.5kg (379.0mol, 1.2 equiv.). The reaction system was heated to reflux, HPLC detected until the end of the reaction. The system pushed A saturated aqueous solution of sodium bisulfite in 480.0kg (5mL / g) to terminate the reaction. Standing, liquid separation, The organic phase was concentrated, then ethanol was added 126.4kg (2mL / g) was recrystallized from 2-bromo-halo 3- (4-fluorophenyl) -1-isopropyl–1H- indole 89.2kg, 96.0% pure liquid, yield 85.0%.
93957-49-4 3-(4-Fluorophenyl)-1-isopropyl-1H-indole 736229, aindole-building-block compound, is more and more widely used in various.
Reference£º
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Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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