Anderson, Kirsty published the artcileOne-pot oxidative hydrolysis-oxidative cleavage of 7-borylindoles enables access to o-amidophenols and 4-acylbenzoxazoles, COA of Formula: C15H20BNO2, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(24), 3559-3562, database is CAplus and MEDLINE.
The compounds 7-borylindoles I (R1 = H, Me, n-Pr, BPin, Ph, 4-fluorophenyl; R2 = H, Me, Et, 4-methoxyphenyl; R3 = H, Me, F, Cl, Br, NO2, BnO) undergo a one-pot oxidative-hydrolysis of the arylboronate and oxidative cleavage of the indole C2-C3 double bond to afford o-amidophenol derivatives 2-OH-4-R3-6-(R2C(O))-C6H2NHC(O)R1. Subsequent cyclization delivers benzoxazoles II bearing an acyl group at C4, a substitution pattern common to fungal-derived benzoxazole alkaloids. Using 7-borylindoles I as substrates to access functionalized o-amidophenols, the difficult preparation of these compounds from arene, streamlining access to substituted 4-acylbenzoxazoles II in the process is circumvented.
Chemical Communications (Cambridge, United Kingdom) published new progress about 919119-59-8. 919119-59-8 belongs to indole-building-block, auxiliary class Indole,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole, and the molecular formula is C15H20BNO2, COA of Formula: C15H20BNO2.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles