On August 14, 2006, Andersson, Fredrik; Hedenstroem, Erik published an article.Recommanded Product: 79815-20-6 The title of the article was Synthesis of two (S)-indoline-based chiral auxiliaries and their use in diastereoselective alkylation reactions. And the article contained the following:
Two chiral auxiliaries, 2-[(S)-indolin-2-yl]propan-2-ol (I) and (S)-2-(2-methoxypropan-2-yl)indoline, were synthesized from enantiomerically pure (S)-indoline-2-carboxylic acid. High diastereoselectivities in alkylations of enolates of the propanoylamides derived from the two auxiliaries are presented. Surprisingly, both auxiliaries induced the same selectivity at the newly created stereogenic center. The benzyl bromide and Bu iodide alkylation reactions showed diastereomeric ratios that were moderate (81:19) to very good (96:4) and with very good yields (86-98%). When LiCl was used as an enolate coordinating agent, in the benzylation of the enolate from propanoylated auxiliary I, a very high crude diastereomeric ratio was obtained (99.7:0.3). The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Recommanded Product: 79815-20-6
The Article related to acylindolinemethanol chiral auxiliary stereoselective alkylation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Recommanded Product: 79815-20-6
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles