Liu, Jiang;Wang, Luyao;Guo, Na;Teng, Yu-Ou;Yu, Peng published 《Design, synthesis and biological evaluation of the novel isoindolinone derivatives》 in 2014. The article was appeared in 《Journal of Chemical and Pharmaceutical Research》. They have made some progress in their research.SDS of cas: 132680-54-7 The article mentions the following:
A series of novel isoindolinone derivatives I [R = morpholino, pyrrolidino, N-Boc-piperazino, piperazino] were designed, synthesized and screened for their antitumor activity against HT-29, K562 and HepG2 cell lines. Among the tested compounds, isoindolinone derivative I [R = N-Boc-piperazino] exhibited good antitumor activity against HepG2 cancer cell line with IC50 of 5.89 μM. And 6-Methoxyisoindolin-1-one (cas: 132680-54-7) was used in the research process.
The crystal structure of 6-Methoxyisoindolin-1-one(cas:132680-54-7 SDS of cas: 132680-54-7) has been determined using x-ray crystallography and cell studies. It was found that 6-Methoxyisoindolin-1-one inhibits the interactions of chk1 with substructures of DNA, such as the major groove and minor groove.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles