Wang, Ze-Shu;Chen, Yang-Bo;Zhang, Hao-Wen;Sun, Zhou;Zhu, Chunyin;Ye, Long-Wu published 《Ynamide Smiles Rearrangement Triggered by Visible-Light-Mediated Regioselective Ketyl-Ynamide Coupling: Rapid Access to Functionalized Indoles and Isoquinolines》. The research results were published in《Journal of the American Chemical Society》 in 2020.Product Details of 132680-54-7 The article conveys some information:
Here, a novel and practical radical Smiles rearrangement triggered by photoredox-catalyzed regioselective ketyl-ynamide coupling is reported, which represents the first radical Smiles rearrangement of ynamides. This method enables facile access to a variety of valuable 2-benzhydrylindoles with broad substrate scope in generally good yields under mild reaction conditions. In addition, this chem. can also be extended to the divergent synthesis of versatile 3-benzhydrylisoquinolines through a similar ketyl-ynamide coupling and radical Smiles rearrangement, followed by dehydrogenative oxidation Moreover, such an ynamide Smiles rearrangement initiated by intermol. photoredox catalysis via addition of external radical sources is also achieved. By control experiments, the reaction was shown to proceed via key ketyl radical and α-imino carbon radical intermediates. To complete the study, the researchers used 6-Methoxyisoindolin-1-one (cas: 132680-54-7) .
6-Methoxyisoindolin-1-one(cas:132680-54-7 Product Details of 132680-54-7) also interacts with inhibitors of other topoisomerases such as camptothecin and etoposide. It has been shown that combining these two drugs can inhibit cancer cells more effectively than either drug alone.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles