The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1,4-Dibromobutane( cas:110-52-1 ) is researched.COA of Formula: C4H8Br2.Feng, Yiyue; Lu, Yingmei; Li, Junfang; Zhang, Honghua; Li, Zhao; Feng, Hanzhong; Deng, Xuemei; Liu, Dan; Shi, Tao; Jiang, Weifan; He, Yongxing; Zhang, Jian; Wang, Zhen published the article 《Design, synthesis and biological evaluation of novel o-aminobenzamide derivatives as potential anti-gastric cancer agents in vitro and in vivo》 about this compound( cas:110-52-1 ) in European Journal of Medicinal Chemistry. Keywords: o aminobenzamide antigastric cancer agents; Cell cycle analysis; Gastric cancer; Migration and invasion; Structure-activity relationship; o-Aminobenzamide derivatives. Let’s learn more about this compound (cas:110-52-1).
Although gastric cancer has become a major public health problem, oral agents applied in clinics for gastric cancer therapy are scarce. Therefore, to explore new oral chem. entities with high efficiency and low toxicity, 41 o-aminobenzamide derivatives based on the scaffolds of MS-275 and SAHA were designed, synthesized, and evaluated for their anti-gastric cancer abilities in vitro and in vivo. Structure-activity relationships were discussed, leading to the identification of compounds F8 (IC50 = 0.28 μM against HGC-27 cell) and T9 (IC50 = 1.84 μM against HGC-27 cell) with improved cytotoxicity, anti-gastric cancer proliferation potency, induction of cell apoptosis and cell cycle arrest ability, inhibition of cell migration and invasion. What is worth mentioning is that compound F8 was more efficient and less toxic than the pos. drug capecitabine in vivo on the HGC-27-xenograft model. Meanwhile, compound F8 exhibited suitable pharmacokinetic properties and less acute toxicity (LD50 > 1000 mg/kg). Besides, western blotting anal., IHC anal., differentially expressed proteins anal. and ABPP experiment indicated that compound F8 could modulate mol. pathways involved in apoptosis and cell cycle progression. Consequently, compound F8 is a strong candidate for the development of human gastric cancer therapy.
If you want to learn more about this compound(1,4-Dibromobutane)COA of Formula: C4H8Br2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(110-52-1).
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles