Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ Safety of 2,3,3-Trimethylindolenine, Which mentioned a new discovery about 1640-39-7
Near-infrared dye, its targeting imaging agent, nano-carrier and anti-cancer drug and application (by machine translation)
This invention relates to a near-infrared fluorescent dye, its construction of targeted imaging agent, nano-carrier and anti-cancer drug and application. The invention said near infrared fluorescent dyes with the hydrophilic glycodendrimer through environmental sensitive key connected to form having self-assembling ability of the amphiphilic dendrimers. Hydrophilic dendrimers to lysine and arginine as the skeleton structure, has good tumor target and puts on the membrane. Amphipathic molecule also having a nitro reductase response, can be self-assembled into nano liposome or micelle or vesicle, for gene and/or pharmaceutical carrier, the carrier in the tumor micro-environment de-assembly, and/or drug release gene, in order to realize the purpose of treatment. The amphiphilic molecule also can be in the near-infrared illumination to generate active oxygen, can be used for photodynamic therapy. Said molecule self-assembly after assembling the front and rear reconciliation are fluorescent quenching state, only in the tumor cell nitro reductase under the action of the strong fluorescent will only be, and penetration force is stronger, more precise. (by machine translation)
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Safety of 2,3,3-Trimethylindolenine, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 1640-39-7
Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles