Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Ayipo, Yusuf Oloruntoyin, once mentioned the application of 34580-14-8, Name is Ketotifen fumarate, molecular formula is C23H23NO5S, molecular weight is 425.4974, MDL number is MFCD00079394, category is indole-building-block. Now introduce a scientific discovery about this category, COA of Formula: C23H23NO5S.
Neuropharmacological potentials of beta-carboline alkaloids for neuropsychiatric disorders
Neuropsychiatric disorders are diseases of the central nervous system (CNS) which are characterised by complex pathomechanisms that including homeostatic failure, malfunction, atrophy, pathology remodelling and reactivity anomaly of the neuronal system where treatment options remain challenging. beta-Carboline (beta C) alkaloids are scaffolds of structurally diverse tricyclic pyrido [3,4-b]indole alkaloid with vast occurrence in nature. Their unique structural features which favour interactions with enzymes and protein receptor targets account for their potent neuropharmacological properties. However, our current understanding of their biological mechanisms for these beneficial effects, especially for neuropsychiatric disorders is sparse. Therefore, we present a comprehensive review of the scientific progress in the last two decades on the prospective pharmacology and physiology of the beta C alkaloids in the treatment of some neuropsychiatric conditions such as depression, anxiety, Alzheimer’s disease, Parkinson’s disease, brain tumour, essential tremor, epilepsy and seizure, licking behaviour, dystonia, agnosia, spasm, positive ingestive response as demonstrated in non-clinical models. The current evidence supports that beta C alkaloids offer potential therapeutic agents against most of these disorders and amenable for further drug design.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles