Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Safety of Trimethoprim738-70-5, Name is Trimethoprim, SMILES is NC1=NC=C(CC2=CC(OC)=C(OC)C(OC)=C2)C(N)=N1, belongs to indole-building-block compound. In a article, author is Sviridova, Lyudmila A., introduce new discover of the category.
Boron trifluoride-catalyzed amidoalkylation of indole derivatives with 5-hydroxy-1-phenylimidozolidin-2-one affords new biheterocycles with a direct C-C bond. Among them, 3- or 2-(2-oxoimidazolidin-5-yl)indoles manifest anti-inflammatory activity with relatively low toxicity.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 738-70-5. Safety of Trimethoprim.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles