On August 31, 1995, Arnold, Lee D. published a patent.Electric Literature of 52537-00-5 The title of the patent was Preparation of 4-(heterocyclyl)quinazoline-derivative anticancer agents. And the patent contained the following:
The title compds [I; R1 = (un)substituted alkyl, halogen, NO2, OH, NH2, alkoxy, heterocyclo, PhO, etc.; Z = (un)substituted heterocyclo; m = 0-3], useful for the treatment of abnormal proliferation due to cancer (no data), psoriasis (no data), benign prostatic hypertrophy (no data), etc. (no data), are prepared Thus, 6-chloroindoline was reacted with 4-chloro-6,7-(ethylenedioxy)quinazoline and pyridine, producing 4-(6-chloro-2,3-dihydroindol-1-yl)-7,8-dihydro[1,4]dioxino[2,3-g]quinazoline, m.p. 209-211°. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Electric Literature of 52537-00-5
The Article related to anticancer agent preparation heterocyclylquinazoline, psoriasis treatment preparation heterocyclylquinazoline, benign prostatic hypertrophy treatment preparation heterocyclylquinazoline, cell proliferation abnormal prevention preparation heterocyclylquinazoline, quinazoline heterocyclyl and other aspects.Electric Literature of 52537-00-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles