On December 19, 1996, Arnold, Lee D.; Moyer, Mikel P.; Sobolov-jaynes, Susan B. published a patent.COA of Formula: C8H8ClN The title of the patent was Preparation of heterocyclic ring-fused pyrimidines for treatment of hyperproliferative diseases. And the patent contained the following:
The title compounds [I; Y = (un)substituted unsaturated or aromatic 5- or 6-membered ring (together with the carbons to which it is attached) containing one to three heteroatoms such as S, O, N (at least one of said heteroatoms is N); Z = NR1R2 (wherein R1 = H; R2 = (un)substituted Ph, heterocycle)], useful in the treatment of hyperproliferative diseases, such as cancers, and psoriasis or benign prostatic hyperplasia, were prepared Thus, reaction of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine with 3-aminophenylacetylene in pyridine afforded 12% II.HCl. In general, compounds I were effective at 0.2-2.5 g/day for an average 70 kg human. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).COA of Formula: C8H8ClN
The Article related to pyrimidine heterocyclyl fused preparation hyperproliferative disease, antitumor agent heterocyclopyrimidine fused preparation, psoriasis heterocyclopyrimidine fused preparation, benign prostatic hyperplasia heterocyclopyrimidine fused preparation and other aspects.COA of Formula: C8H8ClN
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles