On April 7, 1998, Arnold, Lee D. published a patent.HPLC of Formula: 52537-00-5 The title of the patent was Preparation of 4-heterocyclylquinazolines as anticancer agents.. And the patent contained the following:
Title compounds [I; Z = specified (substituted) N-heterocyclyl; R1 = CF3, halo, NO2, OH, amino, cyano, alkyl, alkoxy, alkoxycarbonyl, alkanoyloxy, alkanoylamino, CO2H, PhO, PhCO2, carbamoyl, hydroxyalkyl, alkylthio, anilino, pyrrolidinyl, etc.; m = 0-3], were prepared as neoplasm inhibitors (no data). Thus, 6-chloroindoline, 4-chloro-6,7-ethylenedioxyquinazoline, and pyridine were refluxed in iPrOH to give 4-(6-chloro-2,3-dihydroindol-1-yl)-7,8-dihydro[1,4]dioxino[2,3-g]quinazoline. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).HPLC of Formula: 52537-00-5
The Article related to heterocyclylquinazoline preparation anticancer, quinazoline heterocyclyl preparation anticancer, hyperproliferative disorder treatment heterocyclylquinazoline, indolylquinazoline preparation anticancer and other aspects.HPLC of Formula: 52537-00-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles