Awesome and Easy Science Experiments about 100-51-6

SDS of cas: 100-51-6. About Benzyl Alcohol, If you have any questions, you can contact Shang, XJ; Zhang, C; Zhao, J; Shao, P; Lu, HJ; Yan, FL or concate me.

SDS of cas: 100-51-6. Authors Shang, XJ; Zhang, C; Zhao, J; Shao, P; Lu, HJ; Yan, FL in WILEY-V C H VERLAG GMBH published article about in [Shang, Xiao-Jun; Zhang, Chong; Zhao, Jie; Lu, Hui-Juan; Yan, Fu-Lin] Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China; [Shang, Xiao-Jun] Xinxiang Med Univ, Affiliated Hosp 1, Weihui 453100, Henan, Peoples R China; [Shao, Peng] Zhengzhou Univ, Zhengzhou Cent Hosp, Zhengzhou 450007, Henan, Peoples R China in 2019.0, Cited 13.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

The aim of this study was to determine the antitumor activity of diterpenoid compounds. A series of modified diterpenoid derivatives (3-26) were obtained from the natural products enmein (1) and nodosin (2), using simple synthetic methods. The structures of the synthesized compounds were established through H-1 NMR, C-13 NMR and HRMS. The compounds were screened using a CCK8 assay for their antiproliferative activities against K562 and HepG2 human cancer cells. Most of the target compounds showed improved antiproliferative activity against K562 and HepG2 human cancer cells compared with natural enmein (1) and nodosin (2). 6-Propynyloxy-enmein (13), 6- propynyloxy-nodosin (25) and 6-cyclopropylmethoxy-nodosin (26) exhibited strong inhibitory activity against K562 cells with IC50 values of 3.58 +/- 0.16, 1.89 +/- 0.18, and 4.86 +/- 0.30 mu g/mL, respectively.

SDS of cas: 100-51-6. About Benzyl Alcohol, If you have any questions, you can contact Shang, XJ; Zhang, C; Zhao, J; Shao, P; Lu, HJ; Yan, FL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles