Safety of 4-Methoxybenzaldehyde. Authors Zeid, SB; Hamade, A; Najjar, F; Carreaux, F; Eid, S in SPRINGER INTERNATIONAL PUBLISHING AG published article about in [Zeid, Samar Bou; Hamade, Aline; Najjar, Fadia; Eid, Samar] Lebanese Univ, Fac Sci 2, Dept Biol Chem & Biochem, Lab Innovat Therapeut, Fanar, Lebanon; [Zeid, Samar Bou; Carreaux, Francois] Univ Rennes 1, CNRS, ISCR, UMR 6226, 263 Ave Gen Leclerc,Campus Beaulieu, F-35000 Rennes, France in 2021, Cited 43. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5
Herein we describe the synthesis of five new 2-aryl and 2-alkylimidazolone derivatives via an effective one-pot synthetic strategy assisted by microwave irradiations which allowed us to access the desired product in a reduced time reaction compared to the thermal heating and a slightly better yield (48% compared to 45%). The new imidazolone derivatives were evaluated for their anticancer activity in vitro against MCF-7, MDA-MB-231 and HepG2 cell lines. The results showed good cytotoxic effects for some of these derivatives on both MCF-7 and HepG2 cell lines in the range of 5.7-11.3 mu M. Among the synthesized derivatives, 2ab and 2b showed the strongest activity with IC50 values of 7 and 5.7 mu M (MCF-7) and 6.2 and 8.6 mu M (HepG2), respectively. The cytotoxic activities of these derivatives were moderate compared to those of doxorubicin. However, this product showed higher toxicity in vivo on the development of zebrafish embryos than the synthesized imidazolones. These derivatives at high concentrations exhibited some morphological abnormalities on the embryos.
Safety of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zeid, SB; Hamade, A; Najjar, F; Carreaux, F; Eid, S or concate me.
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,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles