In an article, author is Guo, Yang, once mentioned the application of 1761-61-1, SDS of cas: 1761-61-1, Name is 5-Bromo-2-hydroxybenzaldehyde, molecular formula is C7H5BrO2, molecular weight is 201.02, MDL number is MFCD00003330, category is indole-building-block. Now introduce a scientific discovery about this category.
The activity and selectivity of activated-carbon-supported Ni, Pt, Ru, and Ni-Ru bimetallic catalysts was examined for hydrothermal denitrogenation of indole. The molar yield of pyrrole ring-opening compounds, without an added hydrogen source, are in the order: Ni < Pt < Ni9oRu10 < Ni75Ru25 < Ni50Ru50 similar to Ni25Ru75 similar to Ru. Ru-containing catalysts facilitated pro- duction of hydrocarbons (hydrodenitrogenation (HDN) products) when used with added formic acid (hydrogen source). We elucidated catalytic hydrothermal HDN pathways for indole based on the product distributions and the variation of their yields with time. Hydrogenation of indole to indoline is the primary pathway and ring-opening of indoline to form alkyl anilines is faster than forming HDN products (alkyl benzenes). DFT calculations confirmed experimental activity trends, showing Ru is more active than Ni for indole ring opening and for o-toluidine deamination. If no hydrogen source is present, directly breaking the N-C bond in the pyrrole ring is more favorable than breaking the C-N bond with an aromatic carbon. If a H source is provided, the pyrrole ring hydrogenates first, forming indoline, followed by cleavage of the C-N bond. If you are interested in 1761-61-1, you can contact me at any time and look forward to more communication. SDS of cas: 1761-61-1.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles