Synthetic Route of 21799-87-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 21799-87-1, Name is Potassium 2,5-dihydroxybenzenesulfonate, SMILES is [K+].OC1=CC(=C(O)C=C1)S([O-])(=O)=O, belongs to indole-building-block compound. In a article, author is Kaur, Pavneet, introduce new discover of the category.
Metal-Free Multicomponent Construction of Tetrahydroisoquinoline-Indole Derivatives via In Situ Generated ortho-Quinonoid Intermediate
A metal- and ligand-free multicomponent coupling of tetrahydroisoquinoline (THIQ), ortho-hydroxybenzaldehydes and indoles under solvent-free conditions is described. The developed protocol provided a waste-free and concise access to C(1)-functionalized THIQ-indole derivatives under green conditions. The reactant molar ratio and neutral conditions were found crucial for controlling the selectivity of desired THIQ-indole product over competitive by-products i. e. oxazine and bis(indolyl)methane. The experimental and DFT study revealed the involvement of ortho-quinonoid species which reacts with indoles in situ to form THIQ-indole derivatives.
Synthetic Route of 21799-87-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 21799-87-1.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles