In an article, author is Qiu, Xiaodong, once mentioned the application of 27955-94-8, Name is 4,4′,4”-(Ethane-1,1,1-triyl)triphenol, molecular formula is C20H18O3, molecular weight is 306.36, MDL number is MFCD00012180, category is indole-building-block. Now introduce a scientific discovery about this category, Name: 4,4′,4”-(Ethane-1,1,1-triyl)triphenol.
The indole scaffold will continue to play a vital role in the future of drug discovery and agrochemical development. Regioselective direct arylation of indoles on the benzenoid moiety is a challenging task due to the inherent reactivity of the C2 and C3 positions. Here, we have developed an effective strategy for the regioselective direct arylation of indoles at the C7 position with (hetero)aryl bromides by the rational design of a directing group. The key to the high selectivity and reactivity of this method is the appropriate selection of a class of directing groups, N-PR2 (R = Bu-t and (c)Hex), that are easily removed in the presence of the Wilkinson’s catalyst. Using the present method as a key step, formal synthesis of marine alkaloid dictyodendrin B has also been demonstrated.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles