An article A new antifungal aminobenzamide derivative from the endophytic fungus Fusarium sp. WOS:000468924000005 published article about TETRACYCLIC TRITERPENOIDS; FUSARITHIOAMIDE; BUTYROLACTONES in [Ibrahim, Sabrin R. M.; Al Haidari, Rwaida A.; Zayed, Mohamed F.] Taibah Univ, Coll Pharm, Dept Pharmacognosy & Pharmaceut Chem, Al Madinah Al Munawwarah, Saudi Arabia; [Ibrahim, Sabrin R. M.] Assiut Univ, Fac Pharm, Dept Pharmacognosy, Assiut, Egypt; [Mohamed, Gamal A.] King Abdulaziz Univ, Fac Pharm, Dept Nat Prod & Alternat Med, Jeddah, Saudi Arabia; [Mohamed, Gamal A.] Al Azhar Univ, Assiut Branch, Fac Pharm, Dept Pharmacognosy, Assiut, Egypt; [Khayat, Maan T.] King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut Chem, Jeddah, Saudi Arabia; [El-Kholy, Amal A.] Taibah Univ, Coll Pharm, Dept Clin & Hosp Pharm, Al Madinah Al Munawwarah, Saudi Arabia; [El-Kholy, Amal A.] Ain Shams Univ, Dept Clin Pharm, Fac Pharm, Cairo, Egypt; [Zayed, Mohamed F.] Al Azhar Univ, Dept Pharmaceut Chem, Fac Pharm, Cairo, Egypt in 2019.0, Cited 17.0. Quality Control of 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4
Background: Endophytic fungi attracted attention as a prolific source of bioactive natural products with a potent pharmaceutical activity and unique structure. Objective: The main goal of the study is to separate and identify the bioactive constituents from the endophytic fungus Fusarium sp. as well as to evaluate the antimicrobial of the new metabolites. Materials and Methods: The fungus was cultured on a rice medium, and then, the cultures were extracted with ethyl acetate (EtOAc). The EtOAc extract was chromatographed utilizing different chromatographic methods to give five metabolites. The structural determination of these metabolites was carried out by the analyses of various spectroscopic data, in addition to comparison with the formerly reported data. The antifungal and antibacterial potentials were evaluated toward various microbial strains using disc diffusion assay. Results: A new aminobenzamide derivative, namely fusaribenzamide A (2), and four known metabolites: (22E,24R)-stigmasta-5,7,22-trien-3–ol (1), adenosine (3), p-hydroxyacetophenone (4), and tyrosol (5) were isolated. Fusaribenzamide A (2) possessed significant antifungal activity toward Candida albicans with minimum inhibitory concentration (MIC) value 11.9 mg/disc compared to nystatin (MIC 4.9 mg/disc). Conclusion: The endophytic fungus Fusarium sp. could be considered as a wealthy pool for the isolation of aminobenzamide derivatives. Fusaribenzamide A may be a candidate for the discovery of a promising antifungal agent.
Quality Control of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Ibrahim, SRM; Mohamed, GA; Khayat, MT; Al Haidari, RA; El-Kholy, AA; Zayed, MF or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles