Chemistry, like all the natural sciences, Quality Control of Flurbiprofen, begins with the direct observation of nature— in this case, of matter.5104-49-4, Name is Flurbiprofen, SMILES is O=C(O)C(C)C1=CC=C(C2=CC=CC=C2)C(F)=C1, belongs to indole-building-block compound. In a document, author is Wen, Ren, introduce the new discover.
A one-pot, five-component strategy toward the synthesis of new indole substituted pyrrolidine and pyrrolizidine heterocycles through 1,3-dipolar cycloaddition reactions using ninhydrin, 1,2-phenylenediamine, amino acids, 3-cyanoacetyl indoles and aryl aldehydes is described. The features of this procedure were characterized by the mild reaction conditions, high yields, one-pot procedure, and operational simplicity. (C) 2018 Elsevier Ltd. All rights reserved.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 5104-49-4. Quality Control of Flurbiprofen.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles