Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.520-36-5, Name is Apigenin, SMILES is O=C1C=C(C2=CC=C(O)C=C2)OC3=C1C(O)=CC(O)=C3, belongs to indole-building-block compound. In a document, author is Avadhani, Anusha, introduce the new discover, Quality Control of Apigenin.
Aza-annulation of novel 1,2,3,4-tetrahydro-beta-carboline derived enaminones and nitroenamines with various 1,2- and 1,3-bis electrophiles, such as oxalyl chloride, maleic anhydride, 1,4-benzoquinone, 3-bromopropionyl chloride, itaconic anhydride, and imines (from formaldehyde and primary amines), has been investigated. These methodologies provide simple one-step pathways for efficient construction of highly functionalized tetrahydro-beta-carboline 1,2-fused, five- and six-membered heterocyclic frameworks, such as indolizino[8,7-b]indoles, pyrido[1,2-a:3,4-b’]-diindoles, indolo[2,3-a] quinolizidines, and pyrimido[1′,6′:1,2]-pyrido[3,4-b]indoles, which are core structures of many naturally occurring indole alkaloids with diverse bioactivity.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 520-36-5. Quality Control of Apigenin.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles