Chemistry is an experimental science, COA of Formula: C10H9NO2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 70555-46-3, Name is 6-Methoxy-1H-indole-3-carbaldehyde
A new library of thirteen indolylisoxazolines 6a?m has been synthesized by the treatment of indolylchalcones with hydroxylamine hydrochloride. Evaluation of anticancer activity of indolylisoxazolines 6a?m led to the identification of potent compounds 6c?d, 6i and 6l, with IC50 ranging 2.5?5.0 muM against the tested cancer cell lines. Using a number of complementary techniques such as acridine orange/ethidium bromide staining, PARP1 cleavage and DNA strand breaks assay, we show that the compounds 6c and 6i induce apoptosis in highly aggressive C4-2 cells. Our data further revealed that 6c and 6i inhibited C4-2 cells proliferation without inducing reactive oxygen species (ROS). Finally, we show that compounds 6c and 6i also potently inhibit cell migration, indicating these compounds have the potential to serve as effective anti-cancer agents.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C10H9NO2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 70555-46-3, in my other articles.
Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles