Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Category: indole-building-block90-45-9, Name is 9-Aminoacridine, SMILES is NC1=C(C=CC=C2)C2=NC3=CC=CC=C31, belongs to indole-building-block compound. In a article, author is Pillaiyar, Thanigaimalai, introduce new discover of the category.
A rapid, efficient and versatile green synthesis of 3,3 ‘-diindolylmethanes
The natural product 3,3’-diindolylmethane (DIM) exhibits anti-cancer and immunostimulatory properties. We report an operationally simple, efficient and versatile synthesis of DIM derivatives by reaction of indoles with aldehydes in the presence of sulfuric acid in water. Short reaction times of only 5 min, simple work-up procedure, avoidance of hazardous organic solvents, and excellent yields are apparent advantages of this method. The synthetic protocol tolerates a broad range of functional groups allowing fast and straightforward access to a large variety of DIM derivatives, including 20 new compounds not previously described in literature, which have potential as anti-cancer drugs. [GRAPHICS] .
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 90-45-9. Category: indole-building-block.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles