In an article, author is Ostacolo, Carmine, once mentioned the application of 480-18-2, Application In Synthesis of (2R,3R)-Taxifolin, Name is (2R,3R)-Taxifolin, molecular formula is C15H12O7, molecular weight is 304.2516, MDL number is MFCD15146487, category is indole-building-block. Now introduce a scientific discovery about this category.
Ultrasound-promoted N-aminomethylation of indoles can be achieved in basic medium using sodium hydride and dichloromethane (DCM) as C1 donor source. This innovative amino methylation protocol results in good to excellent yields of multifunctional indole derivatives. The procedure is also applicable to other aza-heterocyclic compounds and, interestingly, affords direct access to aminomethyl-substituted aryl alcohols.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles