Recently I am researching about POLO-LIKE KINASE; CANCER, Saw an article supported by the China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019TQ0215]; Program of Liaoning Revitalization Talents Program [XLYC1808037]; Doctoral Scientific Research Foundation of Liaoning Province [2020-BS-130]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Li, ZW; Xu, L; Zhu, LY; Zhao, YF; Hu, T; Yin, BX; Liu, YJ; Hou, YL. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Quality Control of 3-Hydroxybenzaldehyde
A series of novel pteridinone derivatives possessing a hydrazone moiety were designed, synthesized and evaluated for their biological activity. Most of the synthesized compounds demonstrated moderate to excellent activity against A549, HCT116 and PC-3 cancer cell lines. In particular, compound L-19 exhibited the most potent antiproliferative effects on three cell lines with IC50 values of 3.23 mu M, 4.36 mu M and 8.20 mu M, respectively. In kinase assays, the compound L-19 also showed potent inhibition activity toward PLK1 with % inhibition values of 75.1. Further mechanism studies revealed that compound L-19 significantly inhibited proliferation of HCT-116 cell lines, induced a great decrease in mitochondrial membrane potential resulting in apoptosis of cancer cells, inhibited the migration of tumor cells, and arrested G1 phase of HCT116 cells.
Quality Control of 3-Hydroxybenzaldehyde. Welcome to talk about 100-83-4, If you have any questions, you can contact Li, ZW; Xu, L; Zhu, LY; Zhao, YF; Hu, T; Yin, BX; Liu, YJ; Hou, YL or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles